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Buy Estradiol online next day delivery

Estradiol medication used to reduce moderate to severe menopausal symptoms, to treat vulval and vaginal atrophy, treat certain cancers in special situations and prevent the thinning of bones.

Generic Estradiol name: Estrace.

Normal dose of estradiol is 1mg or 2mg tablet daily.

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More Estradiol information

Drug Uses

Estradiol Valerate is a hormone replacement therapy (HRT) used to substitute for a lack of oestrogen production by the ovaries that happens during menopause or following surgical removal of the ovaries, to relieve symptoms of menopause caused by oestrogen deficiency, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy.

Estradiol Valerate is also used to help prevent postmenopausal bone loss (osteoporosis) and reduce risk of fracture. It stimulates the development of female sexual characteristics, and is used as the oestrogen component of transgender hormone therapy for male to female transsexuals.

How does Progynova work

Progynova contain oestradiol valerate, a prodrug (or precursor) of natural human oestradiol, which is the major and most active form of the female sex hormone oestrogen, produced by the ovaries. Oestrogen is a steroid hormone that binds to specific receptors inside oestrogen-responsive cells and stimulates them to make proteins involved in producing female sexual characteristics, such as breast development and in regulating the menstrual cycle.

Oestrogen also has several other actions in various metabolic processes including maintaining bone mass and lipid (fat) metabolism.

What does Progynova contain

Progynova contains the active ingredient estradiol valerate, a prodrug (or precursor) of 17β-estradiol, the major and most active form of oestrogen produced by the ovaries, and is used for hormone replacement therapy (HRT). Progynova also contains lactose monohydrate, maize starch, polyvidone 25 000, talc, magnesium stearate, sucrose, polyvidone 700 000, macrogol 6000, calcium carbonate, glycerol 85%, titanium dioxide, indigo carmine lake, montanglycol wax.

Treating symptoms of menopause

Estradiol Valerate is used to treat symptoms caused by a lack of endogenous oestrogen (produced by the ovaries), which happens during menopause, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy.

Side Effects

The most frequently reported side effects when taking Estradiol Valerate are:
breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia and depression.

More severe side effects include changes in liver function at higher doses and increased risk of dementia if initiated in women aged 65 or older.

What are the health risks of Progynova?

Long-term HRT does have associated health risks, including an increased risk of breast cancer, endometrial cancer, stroke and deep vein thrombosis. For women with an intact uterus adding a progestogen to an oestrogen replacement regimen like Progynova for at least 10 days per cycle is recommended to reduce the risk of endometrial cancer.


You should not use this remedy if you:

  • are allergic to oestradiol valerate or any ingredients in Progynova
  • have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease
  • have deep venous thrombosis, thromboembolic disorders, cerebral vascular accident associated with oestrogen use
  • have abnormal genital bleeding of unknown cause
  • are pregnant or planning to become pregnant
  • are taking other medications that may interact with Estradiol Valerate, such as anticonvulsants like phenytoin and carbamazepin, barbiturates, anti-infectives like rifampicin, rifabutin, nevirapine, antibiotics like penicillin
  • are a diabetic taking antidiabetics or insulin, without discussion with your doctor, as Estradiol Valerate may affect your glucose tolerance

How taken

You should take Estradiol Valerate with a glass of water once a day, preferably at the same time each day, until all 28 tablets have been taken. The dose you take depends on your condition and should be as recommended by your doctor. When you have finished ach pack, start the next pack immediately. You can start taking Progynova tablets on any convenient day unless you are still having menstrual bleeding, in which case take the first tablet on day 5 of bleeding.

Each pack of Estradiol Valerate is a calendar pack of 28 tablets. You should take it for as long as your doctor recommends.

Missed dose

If you miss a dose take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. If you forget to take a tablet for more than 12 to 24 hours, irregular bleeding may occur.


Keep Estradiol Valerate in their calendar pack until used. Store at room temperature below 25°C, keep away from direct sunlight and do not refrigerate.

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